Dietary interventions for phenylketonuria

The dietary treatment of phenylketonuria.

Phenylketonuria is an inborn error of the metabolism of phenylalanine associated almost invariably with grave mental deficiency, and often with epilepsy resembling petit mal. It was suggested that the mental deficiency was due to an intoxication by phenylalanine or one of its metabolites and might be relieved by feeding a diet low in phenylalanine (Woolf and Vulliamy, 1951). An economically pra...

Changing dietary practices in phenylketonuria.

In recent years, there has been much focus on research on non-dietary treatments in phenylketonuria (PKU). However, diet is likely to remain the major treatment for many years to come, since it has continued to be developed and consistent improvements have occurred. For example, with protein substitute, studies have tried to define the optimal dose and timing of intake; changes in palatability ...

Recommendations on the dietary management of phenylketonuria. Report of Medical Research Council Working Party on Phenylketonuria.

Dietary Interventions in Autism

The objective of this chapter is to evaluate the research pertinent to the use of dietary interventions to treat autism. A brief description, rationale, any evidence of efficacy and validity of methodology employed for most frequently used inventions in autism follows. The number of children diagnosed with autism spectrum disorder (ASD) has increased significantly over the last decades in the U...

Dietary intervention in the management of phenylketonuria: current perspectives

Phenylketonuria (PKU) is a well-described inborn error of amino acid metabolism that has been treated for >60 years. Enzyme deficiency causes accumulation of phenylalanine (Phe) and if left untreated will lead to profound and irreversible intellectual disability in most children. Traditionally, it has been managed with a low-Phe diet supplemented with a Phe-free protein substitute although newe...